Scientists Reach Breakthrough in Low-Toxic Chemotherapy

​The Hebrew University team managed to create a stable titanium-based complex that may substantially reduce side effects
A team of researchers from the Institute of Chemistry in the Hebrew University may have found the key to reducing substantially chemotherapy-associated side effects. The team, led by Prof. Edit Tshuva, worked on creating chemo-therapeutics based on titanium, a metal more biologically friendly than platinum and other substances currently in use. Previous attempts to utilize the low toxic metal have failed, due to its poor water stability and solubility. But Prof. Tshuva managed to overcome that barrier and to create a number of stable anti-tumor Ti (IV) complexes that have been showing great potential in experiments on the cellular level. The researcher aims to reduce side effects even further, by target-releasing the active drug at the desired location in the cancer cell.

Prof. Edit Tshuva from the Institute of Chemistry was granted 1.4 Million Euros for her project project on "Sophisticated Well-Targeted Therapeutic Entities based on Biologically Compatible Ti(IV) Active Cores and Building Blocks” under the 7th Framework programme.

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​Prof. Tshuva at her lab